Current Postdoctoral Fellows and Graduate Students

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Current Postdoctoral Fellows and Graduate Students

	Seong Wook Han, M.D, Ph.D Research Scholar Krannert Institute of Cardiology Indiana University School of Medicine (317)-962-0580 swhan@iupui.edu CV and Publications (.pdf file) • Pubmed Listing

	Soon Jun Hong, M.D., Ph.D. Assistant Professor, Cardiovascular Center, Department of Cardiology, Korea University Anam Hospital, Seoul, Korea (317)-278-0092 soonhung@iupui.edu CV (.pdf file) • Publications (.doc file) • Pubmed Listing

	Jie Xie M.D. Graduate Student (317)-278-0095 jiexie@iupui.edu Ph.D. candidate: Cellular & Integrative Physiology, Indiana University School of Medicine M.D.:Peking Union Medical College, China Crosstalk among different progenitor cell population, including adipose Stromal cells, Endothelial progenitor cells and Hematopoietic stem and progenitor cells, in the process of neovascularization. Pubmed Listing • Biosketch

	Tatsuyoshi Kono, Ph.D. Postdoctoral Fellow Mentor: Carmella Evans-Molina, M.D., Ph.D., Assistant Professor of Medicine / Endocrinology (317)-278-0108 knot@iupui.edu Dr. Kono is working with Dr. Carmella Evans-Molina on islet vascularization, with a particular emphasis on understanding the factors that govern the vascularization of recently transplanted islets, and the dependence of vessel inosculation on circulating and local vascular progenitors. Dr. Kono is co-mentored by Dr. Evans-Molina who serves as a Junior Mentor and Dr. March who serves a Senior Mentor. Pubmed Listing

	Aaron M. Kyle, Ph.D. Postdoctoral Fellow Mentor: Keith March, M.D., Ph.D., Professor of Medicine and Cellular and Integrative Physiology (317)-278-0007 akyle@iupui.edu My name is Aaron Kyle. I am a Biomedical Engineer and post-doctoral fellow at ICVBM. My principal research interest is in the potential therapeutic benefits of different energy types, specifically the effects of applied acoustic or electromagnetic energy on biological systems. My primary project entails investigating the angiogenic effects of pulsed electromagnetic fields (PEMFs). It has been previously demonstrated that PEMF exposure stimulates cellular secretion of angiogenic growth factors, cell proliferation, and accelerated wound healing. We are currently conducting in vitro experiments, exposing vascular progenitor cells to a low energy, FDA approved PEMF signal. We are interested in determining what cellular mechanisms are affected by PEMF and the optimal exposure parameters, e.g. PEMF waveform, frequency, amplitude, that will elicit an angiogenic response. I also specialize biomedical signal processing. I recently designed and implemented digital signal processing algorithms for analysis of arrhythmias in long-duration ECG recordings. Aaron's CV (.doc) file • Pubmed Listing

	Whitney Sealls, Ph.D. Postdoctoral Fellow Mentor: Jeff Elmendorf, M.D., Ph.D., Professor of Cellular and Integrative Physiology (317)-274-7852 wsealls@iupui.edu Dr. Sealls is working with Dr. Jeff Elmendorf on the effects of plasma membrane cholesterol loading on transcriptional factors that in turn affect cholesterol efflux and cellular differentiation. Preliminary data support the concept that plasma membrane cholesterol accrual compromises cellular cholesterol efflux from adipocytes; and they are evaluating the hypothesis both decreased cellular cholesterol efflux and HDL formation are related to transcriptional modulation in this context. The effects of plasma membrane loading on the phenotype and responses of both endothelial and perivascular progenitors will also be evaluated in parallel studies. Pubmed Listing

	Paige Snider, Ph.D. Postdoctoral Fellow Mentor: Simon Conway, Ph.D., Professor (317)-278-8781 psnider@iupui.edu My project is focused on outflow tract development, the pathogenesis of conotruncal heart defects and causes of valvular defects. I have generated and am using several Cre-recombinase reporter and conditional diphtheria toxin-A expressing mice to both identify key cell lineages responsible for causing congenital heart defects and then to genetically ablate them using local diphtheria toxin-A killing. My goal is to correct the various mouse heart malformations and then apply the knowledge gained to help engineer potential treatments for pediatric patients. Pubmed Listing

	Kara Standley, Ph.D. Postdoctoral Fellow Mentors: Simon Conway, Ph.D., Professor of Pediatrics / Cardiology and Mike Sturek, Ph.D. Professor and Chair, Cellular and Integrative Physiology (317)-274-1673 knstandl@iupui.edu Kara Standley worked during the initial portion of her fellowship with Dr. Mike Sturek on the effects of atherogenic diet components on the development of metabolic syndrome and coronary vascular disease in Ossabaw miniature swine; then transitioned into the laboratory of Dr. Simon Conway to extend her study of vascular wall disease into transgenic models. In this laboratory she is studying periostin as a modulator of neointima formation, and specifically testing the hypothesis that tissue-restricted inactivation of Nf1 in either vascular smooth muscle cells or endothelial cells directly leads to increased neointima formation (via Periostin) in response to vascular injury. These studies will then be extended back into porcine models, and ultimately tested in human tissues, in collaboration with other investigators in the ICVBM. Pubmed Listing